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Mainframe is a sentient computer program based upon Tony Stark's brainwaves and is one of the founding members of A-Next.

Origin

In the alternate reality of Earth-928 several years into the future; after seeing so many of his friends and comrades in the Avengers die in their last mission, Tony Stark decided that he could no longer continue as Iron Man and chose to retire. But Stark also realized that the Avengers was too important and to ensure that there would always be an Iron Man to stand at the Avengers' side, devised a special failsafe. He created a special computer program based on his encephalograms and a powerful robotic shell patterned after his Iron Man Armors that he called Mainframe.