They are the main/minor protagonists of the movie National Lampoon's Animal House.
There are best friends with John Bluto Blutarsky.
- Tim Matheson as Eric "Otter" Stratton: A smooth playboy whose room is a pristine seduction den amid the sheer filth of the rest of the Delta house. Otter is the fraternity's rush chairman and essentially the fraternity's unofficial leader. He becomes a gynecologist in Beverly Hills.
- Peter Riegert as Donald "Boon" Schoenstein: Otter's best friend, who has to decide between his Delta pals and girlfriend Katy. He marries Katy in 1964, but they divorce in 1969. In the book adaptation Boon becomes a cab driver and part-time writer in New York City. In "Where Are They Now?" he and Katy remarried, re-divorced, and remarried a final time after a fling resulted in the conception of their son Otis; he also works as a documentarian.
- Thomas Hulce as Lawrence "Pinto" Kroger: A shy but normal fellow, who becomes the editor of National Lampoon magazine. "Pinto" was screenwriter Chris Miller's nickname at his Dartmouth fraternity.
- Stephen Furst as Kent "Flounder" Dorfman: An overweight, clumsy legacy pledge, later a sensitivity trainer in Cleveland.
- Bruce McGill as Daniel Simpson Day, "D-Day": A tough biker with no grade point average; all classes incomplete. His later whereabouts are unknown.
- James Widdoes as Robert Hoover: The affable, reasonably clean-cut president of the fraternity, who desperately struggles to maintain a façade of normality to placate the Dean. These efforts usually end with him willingly going along with the Delta lifestyle. He is at the top of his fraternity with a 1.6 grade point average with 4 C's and one F. He becomes a public defender in Baltimore.
- Douglas Kenney as "Stork": During his first year, everyone thought the Stork was brain damaged; he only speaks two lines in the entire film. He looks especially slovenly and something of a bum. He speaks with something of a country accent. In the book adaptation, Stork is revealed to be independently wealthy as a result of several patents he holds. In "Where Are They Now?" he has died, just as Kenney later died in real life.